recognition and management of platelet‑refractory
· platelet‑refractory bleeding in patients with Glanzmann s thrombasthenia and other severe platelet refractoriness be able to recognize continued internal or external bleeding and know panel which reviewed data on a case-by-case basis using all
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Platelet RefractorinesstouchONCOLOGY
· In our study 20 in which 40 refractory patients received a mean of 14 cross-matched platelet transfusions over a period of 33 months we determined that each refractory patient generated an average expense of €4 325 just for the solid-phase disposable kit required for the selection of compatible platelets. 13 Labour costs should be added to
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PLATELET REFRACTORNINESS Shan Yuan MD (Updated
· Refractory= failure to achieve an acceptable increment in platelet count following platelet transfusion at least on two occasions. Platelet count must be measured within one hour after transfusion b. Rule of thumb a unit apheresis platelet (or a pool of 6 platelet (Panel-reactive antibody) result is the percentage of HLA
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Platelet transfusion refractoriness how do I diagnose and
· It is the residual white blood cells found in cellular blood components that cause HLA alloimmunization. 2 Before the widespread use of leukoreduction platelet refractoriness was seen in 30 to 70 of patients with bone marrow failure 3 however a Canadian study found that leukoreduction lowered HLA alloimmunization from 19 to 7 and alloimmune platelet refractoriness from 14 to
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Management of platelet refractory patients why does
platelet refractory patients Provide HLA/HPA compatible donors from an HLA/HPA typed apheresis donor panel Define HLA/HPA antibody specificity and select antigen compatible apheresis donors Cross-match random apheresis platelets to select compatible donors
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Recognition and management of platelet-refractory bleeding
Recognition and management of platelet-refractory bleeding in patients with Glanzmann s thrombasthenia and other severe platelet function disorders Meera Chitlur 1 Madhvi Rajpurkar 1 Michael Recht 2 Michael D Tarantino 3 Donald L Yee 4 David L Cooper 5 Sriya Gunawardena5 1Carman and Ann Adams Department of Pediatrics Wayne State University and Children rsquos Hospital of Michigan Detroit
Get PriceManagement of platelet refractory patients why does
platelet refractory patients Provide HLA/HPA compatible donors from an HLA/HPA typed apheresis donor panel Define HLA/HPA antibody specificity and select antigen compatible apheresis donors Cross-match random apheresis platelets to select compatible donors
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Platelet transfusion refractorinessHod2008British
· By comparing platelet increments in 40 refractory haematology/oncology patients the mean post-transfusion platelet increment at 1 h was 15·9 10 9 /l in the month prior to initiating crossmatch-compatible therapy and rose to 32 10 9 /l after crossmatch-negative platelet transfusion was implemented (Rebulla et al 2004).
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Platelet and Neutrophil Immunology Laboratory Requisition
· Platelet Antibody Screen (5543) Platelet Transfusion Refractory (PTR) Panel (5632) Platelet Antibody Identification Panel (5608) Post‐Transfusion Purpura (PTP) Panel (5631) (Includes the Platelet Antibody Screen. Detects antibodies to HPA‐1 ‐2 (Each panel includes the Platelet Antibody Identification Panel and the Platelet
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Platelet RefractorinesstouchONCOLOGY
· In our study 20 in which 40 refractory patients received a mean of 14 cross-matched platelet transfusions over a period of 33 months we determined that each refractory patient generated an average expense of €4 325 just for the solid-phase disposable kit required for the selection of compatible platelets. 13 Labour costs should be added to
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Platelet Transfusion for Patients With Cancer American
· The Panel recommends a threshold of < 10 10 9 /L for prophylactic platelet transfusion in adult and pediatric patients undergoing allogeneic hematopoietic stem cell transplantation. Prophylactic platelet transfusion may be administered at higher counts based on clinician judgement.
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Vitalant LaboratoriesPlatelet Testing
Platelet Refractory Panel Platelet Testing Platelet CrossmatchSP The Capture-P Solid Phase System is designed to detect IgG HPA and HLA antibodies. The assay is not designed to detect complement components or antibodies of the IgM or IgA class. Depends upon request See TAT description 3-7 mL EDTA (plasma) or serum (not from gel separator tubes).
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Molecular Testing Red Cross Blood Services
· In platelet refractory patients in whom HLA antibodies have been ruled out it can be used to assess alloimmunization and select platelet products. The HPA-Panel tests for the following (with gene name nucleotide and amino acid information in HGNC nomenclature) HPA-1a/1b HPA-2a/2b in GPIba. GP1BA c.482C/T (T145M) aka Ko b/a HPA-3a/3b in GPIIb
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HLA-Mediated Platelet Refractoriness
Objectives To provide an overview of the complexities associated with the human leukocyte antigen (HLA)-mediated platelet refractoriness. HLA antibody detection technologies and limitations associated with methodologies are discussed. Methods A case scenario and review of relevant literature describing platelet refractoriness are presented followed by a discussion of HLA antibody testing.
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Guidance from the Expert Haematology Panel (EHP) on
· Guidance from the Expert Haematology Panel (EHP) on Covid-19 Vaccine-induced Immune Thrombocytopenia and Thrombosis (VITT) Authors Drs Sue Pavord Will Lester Mike Makris Marie Scully and Beverley Hunt Last update 20.04.2021 . 3 . 6. Platelet transfusion. It is unclear whether platelet transfusions will exacerbate the condition the
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Platelet transfusion refractorinessHod2008British
· By comparing platelet increments in 40 refractory haematology/oncology patients the mean post-transfusion platelet increment at 1 h was 15·9 10 9 /l in the month prior to initiating crossmatch-compatible therapy and rose to 32 10 9 /l after crossmatch-negative platelet transfusion was implemented (Rebulla et al 2004).
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Platelet Refractoriness The Basics
· Platelet refractoriness A patient is refractory to platelet transfusions if the patient s circulating platelet levels consistently fail to increase by at least 10k/µliter after transfusion of an appropriate dose of platelets. Clinical implications.
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PLABNClinical Platelet Antibody Screen Serum
PLABN Platelet antibodies may be allo- or autoantibodies and may be directed to a wide range of antigenic "targets" carried on platelet cytoplasmic membranes. Serum platelet antibody test is optimized to identify the presence of platelet allo-antibodies in the patient. Platelet alloantibodies are involved in several clinical situations such as -Immune mediated refractoriness to platelet
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Platelet Refractoriness Kyle M. Annen DO
Platelet Refractoriness Kyle M. Annen DO Platelet refractoriness is the repeated failure to obtain satisfactory response to platelet transfusion.1 A variety of immune and nonimmune conditions can account for inadequate platelet response and usually the reasons are multifactorial.
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Platelet Transfusion TherapyNIH Consensus Development
· Platelet Transfusion Therapy National Institutes of Health. Consensus Development Conference Statement. October 6-8 1986. This statement is more than five years old and is provided solely for historical purposes. Due to the cumulative nature of medical research new knowledge has inevitably accumulated in this subject area in the time since
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Platelet refractorinesspractical approaches and ongoing
· Platelet refractoriness can represent a significant clinical problem that complicates the provision of platelet transfusions is associated with adverse clinical outcomes and increases health care costs. Although it is most frequently due to non-immune platelet
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Guidance on Platelet Transfusion for Patients with Cancer
· The Panel recommends a threshold of < 10 x 109/L for prophylactic platelet transfusion in adult and pediatric patients undergoing allogeneic HSCT. Prophylactic platelet transfusion may be administered at higher counts based on clinician judgment. (ASCO Q6) • Platelet Count at which Surgical or Invasive Procedures may be
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Platelet Transfusion Refractory PatientsScienceDirect
· Platelet refractoriness is defined as an inappropriately low platelet count increment after platelet transfusion. There are nonimmune and immune causes for platelet refractoriness () with nonimmune causes being responsible for the majority of cases.Evaluation of the potentially platelet refractory patient includes determining the etiology of the underlying thrombocytopenia reviewing the
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recognition and management of platelet‑refractory
· platelet‑refractory bleeding in patients with Glanzmann s thrombasthenia and other severe platelet refractoriness be able to recognize continued internal or external bleeding and know panel which reviewed data on a case-by-case basis using all
Get Price
Providing HLA Compatible Platelets for Refractory Patients
· Platelet Panel Database (PPD) Currently 63 patients nationally require specialised platelet support Most due to platelet transfusion refractoriness Some also in preparation for HLA mismatched stem cell transplant Patient support usually medium to long term range 6 months to 7 years
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Management of platelet refractory patients why does
platelet refractory patients Provide HLA/HPA compatible donors from an HLA/HPA typed apheresis donor panel Define HLA/HPA antibody specificity and select antigen compatible apheresis donors Cross-match random apheresis platelets to select compatible donors
Get Price
Platelet refractoriness Australian Red Cross Lifeblood
· Patients who are refractory to platelet transfusions due to the presence of HLA alloimmunisation. Patients with congenital platelet function disorders such as Bernard–Soulier syndrome Glanzmann s thrombasthenia or other congenital platelet disorders where development of HLA alloantibodies may make future platelet support very difficult.
Get PricePlatelet RefractorinesstouchONCOLOGY
· In our study 20 in which 40 refractory patients received a mean of 14 cross-matched platelet transfusions over a period of 33 months we determined that each refractory patient generated an average expense of €4 325 just for the solid-phase disposable kit required for the selection of compatible platelets. 13 Labour costs should be added to
Get Price
Platelet Antibodies Indirect ARUP Laboratories Test
This test is designed to detect antibodies to platelet glycoproteins IIb/IIIa (HPA-1a/1b PlA1 and PlA2 HPA-3a/3b and HPA-4a) Ia/IIA (HPA-5a/5b) Ib/IX and IV. In addition this test will also detect antibodies to HLA Class I antigens (HLA-A-B). Testing for neonatal alloimmune thrombocytopenia should be performed using a maternal serum
Get PricePlatelet Transfusion TherapyNIH Consensus Development
· Platelet Transfusion Therapy National Institutes of Health. Consensus Development Conference Statement. October 6-8 1986. This statement is more than five years old and is provided solely for historical purposes. Due to the cumulative nature of medical research new knowledge has inevitably accumulated in this subject area in the time since
Get Price
